Vittorio Farina was born in Pisa, Italy. He studied organic chemistry at the University of Pisa, where he received his BS /MS degree. He studied further at the University of Alberta in Edmonton (Canada), where he received a PhD under Prof. Derrick L. J. Clive in 1982. After a 2-year postdoc at Cornell with Prof. John McMurry, he accepted a position in the Chemical Development group at Bristol-Myers in Syracuse (New York). In 1987, he moved to the anticancer research group of Bristol-Myers Squibb in Wallingford, Connecticut. In 1993, he left Bristol-Myers Squibb and joined Boehringer Ingelheim in Ridgefield, Connecticut, where he founded and led the process development department for over a decade. In 2006, he moved back to Europe, accepting a position of Senior Director in the Chemical Development group of Janssen Pharmaceutica in Beerse, Belgium. He has authored over 120 peer-reviewed publications, several books and book chapters and is the inventor of over 20 patents. Vittorio is on the advisory board of Advanced Synthesis and Catalysis, the Beilstein Journal of Organic Chemistry and Organic Reactions, as well as on the board of the Ischia Advanced School of Organic Chemistry and the International Symposium of Homogeneous Catalysis. He also chaired several conferences and symposia, i.a. the 2012 Gordon Research Conference on Stereochemistry. Among his other extracurricular activities, he co-founded ISPROCHEM, an international school of process development that holds short courses in chemical process development, taking place on the banks Lake Garda in Italy.
The focus of the presentation will be on the general problem of the stereospecific coupling of organozinc compounds with glycosyl halides (Scheme 1). Scheme 1: Coupling of diarylzinc derivatives with a protected glucosyl bromide The recently published catalytic methods (Ni, Fe, Co based)1 prompted a study on the non-catalyzed coupling of organozinc derivatives with 1-Br […]